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Oncology 640
640 - General Virology--Multiplication of Viruses
Semester I; 3 credits. Crosslisted with Microbiology 640 and Plant Pathology 640. Lectures on bacterial and animal viruses, their structure, multiplication and genetics.
Prerequisites: Introductory courses in bacteriology, biochemistry, and genetics, or consent of instructor.
Instructors: Paul Ahlquist, Robert Kalejta, and Bryan Sibert.
SYLLABUS
GENERAL VIROLOGY - MULTIPLICATION OF VlRUSES
Bacteriology/Oncology/Plant Pathology 640
FALL SEMESTER, 2009
1:20 pm Mon, Wed, Fri, Room 125 McArdle Laboratory
Paul Ahlquist Professor |
841A Bock Labs; Tel, 263-5916; Email: ahlquist@wisc.edu Office hours: Monday and Wednesday 2:10-3:00 PM |
Robert Kalejta Associate Professor |
635A Bock Labs; Tel, 265-5546; Email: rfkalejta@wisc.edu Office hours: Monday and Wednesday 2:10-3:00 PM |
Bryan Sibert Discussion Leader |
827B Bock Labs; Tel, 265-9742 or 502-432-3104; Email: sibert@wisc.edu Office hours by email or appointment; exam review sessions will be arranged |
| DATE | TOPIC |
| (Sessions in regular type are by Ahlquist, in italics by Kalejta) | |
| Wed., Sept. 2 | Course Introduction / Why and how we study viruses |
| Fri., Sept. 4 | Viruses in the real world: Ebola |
| Mon., Sept. 7 | Labor Day - no lecture |
| Wed., Sept. 9 | Ebola discussion / virus structure and assembly |
| Fri., Sept. 11 | dsRNA viruses |
| Mon., Sept. 14 | dsRNA viruses |
| Wed., Sept. 16 | Picornaviruses |
| Fri., Sept. 18 | Picornaviruses |
| Mon., Sept. 21 | Alphaviruses |
| Wed., Sept. 23 | Alphaviruses |
| Fri., Sept. 25 | Coronaviruses / SARS |
| Mon., Sept. 28 | Exam 1 (100 pts) |
| Wed., Sept. 30 | Retroviruses/HIV |
| Fri., Oct. 2 | Retroviruses/HIV |
| Mon., Oct. 5 | Retroviruses/HIV |
| Wed., Oct. 7 | Retroviruses/HIV |
| Fri., Oct. 9 | Papillomavirus |
| Mon., Oct. 12 | Papillomavirus/Adenovirus |
| Wed., Oct. 14 | Adenovirus |
| Fri., Oct. 16 | Herpesviruses |
| Mon, Oct. 19 | Herpesviruses |
| Wed, Oct. 21 | Herpesviruses |
| Fri., Oct. 23 | Exam 2 (100 pts) |
| Mon, Oct. 26 | Rhabdoviruses |
| Wed., Oct. 28 | Rhabdoviruses |
| Fri., Oct. 30 | Rhabdoviruses / Orthomyxoviruses |
| Mon., Nov. 2 | Orthomyxoviruses |
| Wed., Nov. 4 | Orthomyxoviruses |
| Fri., Nov. 6 | Pandemic flu preparations |
| Mon., Nov. 9 | Genetic variability in viruses |
| Wed., Nov. 11 | RNA interference - discovery and mechanisms |
| Fri., Nov. 13 | RNA interference - antiviral effects and viral modulation of RNAi |
| Mon, Nov. 16 | Plant viruses - initiation and spread of infection |
| Wed., Nov. 18 | Plant resistance responses: relation to animal innate immunity |
| Fri., Nov. 20 | Exam 3 (100 pts) |
| Mon., Nov. 23 | Antiviral Drugs |
| Wed., Nov. 25 | Intrinsic immunity |
| Fri., Nov. 27 | Thanksgiving Recess, No Class |
| Mon., Nov. 30 | Innate immunity |
| Wed., Dec. 2 | Innate immunity |
| Fri., Dec. 4 | Adaptive immunity (B. Sibert) |
| Mon., Dec. 7 | Vaccines (B. Sibert) |
| Wed., Dec. 9 | Poxviruses: virus modulation of immunity; virus control by vaccination |
| Fri., Dec. 11 | Emerging viruses |
| Mon., Dec. 14 | Course Review and Discussion |
| Tues., Dec. 22 |
Comprehensive Final Exam (150
points) 10:05 am - 12:05 am 125 McArdle [The final covers the last 9 lectures (~75 pts) plus comprehensive questions on earlier material (~75 pts).] |
Suggested Texts and References
Principles of Virology: Molecular Biology,
Pathogenesis, and Control (Third Edition,
2009)
Flint, S. J., Enquist, L. W., Racaniello, V. R. &
Skalka, A. M. ASM Press.
Fields Virology (Fifth Edition,
2007)
Knipe, D. and P. Howley (editors). Lippincott,
Williams and Wilkins.
Selected Websites
"All the Virology on the WWW"
http://www.virology.net/
Universal Virus Database of the International Committee on
Taxonomy of Viruses
http://www.ncbi.nlm.nih.gov/ICTVdb/index.htm
NCBI Viral Genomes Resource
http://www.ncbi.nlm.nih.gov/genomes/VIRUSES/viruses.html
Virus World - Structures and Images (UW-Madison Institute
for Molecular Virology)
http://www.virology.wisc.edu/virusworld/viruslist.php
Grading
- Grading is based on exam performance.
- There are three hour exams (100 points each) plus a comprehensive final exam (150 points) for a total of 450 points.
- Separate curves are used for graduate and undergraduate students.
- Examples of prior year exams can be found on the course website. To access this, log on to the MyUW portal at http://my.wisc.edu/ and click on your academic tab. In the list for current courses, this course should contain a link for "library/reserve."
Sample Distribution of Test Scores and Letter
Grades in Previous Years
The following grades and scores are listed for illustration
only and do not necessarily reflect how grades will be
given this year.
|
|
Year |
% of total course points required for indicated grade |
|||||
|
|
|
A |
AB |
B |
BC |
C |
D |
|
Graduate |
2008 |
86 |
83 |
70 |
63 |
55 |
43 |
2007 |
84 |
81 |
70 |
||||
|
2006 |
82 |
78 |
68 |
||||
|
|
2005 |
83 |
79 |
68 |
63 |
55 |
|
|
|
2004 |
83 |
78 |
69 |
66 |
61 |
|
|
|
2003 |
81 |
79 |
70 |
66 |
64 |
|
| 2002 | 84 |
80 |
68 |
55 |
|||
|
|
|
|
|
|
|
|
|
Undergrad |
2008 |
84 |
80 |
67 |
|||
|
|
2007 |
82 |
78 |
67 |
57 |
|
|
|
2006 |
79 |
75 |
65 |
50 |
40 |
||
|
|
2005 |
81 |
|
65 |
56 |
|
|
|
|
2004 |
|
74 |
63 |
59 |
53 |
48 |
|
|
2003 |
75 |
|
68 |
64 |
51 |
|
|
|
2002 |
81 |
|
68 |
64 |
55 |
|
|
|
|
Number of students with indicated
grade |
|||||
|
|
|
A |
AB |
B |
BC |
C |
D |
Graduate |
2008 |
13 |
5 |
15 |
3 |
2 |
1 |
|
|
2007 |
6 |
2 |
8 |
|
|
1 |
|
2006 |
5 |
2 |
6 |
||||
|
|
2005 |
14 |
5 |
12 |
2 |
|
|
|
|
2004 |
10 |
5 |
10 |
1 |
2 |
|
|
|
2003 |
10 |
7 |
14 |
7 |
2 |
|
|
|
2002 |
13 |
13 |
22 |
|
1 |
|
Undergrad |
2008 |
2 |
1 |
5 |
|||
|
|
2007 |
5 |
3 |
6 |
2 |
|
|
|
2006 |
6 |
2 |
5 |
5 |
1 |
||
|
|
2005 |
4 |
|
4 |
2 |
|
|
|
|
2004 |
|
3 |
3 |
1 |
3 |
1 |
|
|
2003 |
1 |
|
3 |
1 |
3 |
|
|
|
2002 |
8 |
|
4 |
3 |
4 |
|