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Oncology 703
703 - Carcinogenesis and Tumor Cell Biology
Semester I; 3 credits. Factors involved in tumor production in humans and experimental animals; biology and biochemistry of neoplasia, both in vivo and in vitro.
Prerequisites: Oncology 401 or equivalent, organic chemistry, biochemistry, cell biology, virology, or consent of instructor.
Instructors: Wei Xu (course director), Caroline Alexander, Chris Bradfield, Paul Lambert, Jing Zhang.
Oncology 703 -
Fall 2009 Course Information
Meeting time/location: 12:05 PM
Monday, Wednesday, and Friday
Room 125 McArdle Laboratory for Cancer Research
Faculty
Wei Xu (course director)
421A McArdle
telephone: 265-5540
wxu@oncology.wisc.edu
Caroline Alexander
819A McArdle
telephone: 265-5182
alexander@oncology.wisc.edu
Chris Bradfield
213A McArdle
telephone: 262-2024
bradfield@oncology.wisc.edu
Paul Lambert
220A McArdle
telephone: 262-8533
lambert@oncology.wisc.edu
Jing Zhang
417A McArdle
telephone: 263-1147
zhang@oncology.wisc.edu
Teaching Approach
This course provides a survey of the molecular mechanisms underlying cancer. The course is taught primarily through the description of experiments that provide new insights in cancer biology. Specific cancers will be emphasized and used to demonstrate central themes in cancer biology. There is a heavy reliance upon reading and understanding primary scientific literature. While the classes are designed primarily around faculty lectures, student participation in class is expected. The course grade is primarily based upon the students' performance in class and their written responses to take home assignments.
Preparation for Each Class
Written material important to the course will be handed out in class. Students should read all handouts for a specific lecture before arriving in class. This includes the background information as well as assigned primary papers. The significance, qualifications, and implications of the studies described in these assigned papers will be discussed in class. The faculty will sometimes ask students to summarize specific experiments described in the assigned papers. Students should be prepared to provide a short description of: (a) the question being asked; (b) the approach used to answer the question; (c) the results obtained; (d) the authors' conclusions drawn from their experiment; and (e) an individual commentary on the value and significance of the experiment.
Exams/Assignments
There are no formal in-class examinations. Instead, students are provided periodic (weekly or more frequent) take-home assignments that involve addressing questions pertaining to a particular reading assignment. Each student is expected to work individually on these assignments. Assignments are to be handed in at the beginning of the class period on the day they are due. Graded assignments will be handed back to students and issues surrounding the answers discussed in class. The goal of these assignments are to foster an appreciation of the primary literature relating to a particular topic and to help students learn to synthesize new ideas and design experiments to test/distinguish between hypotheses.
Help
Students who need any assistance during the course can contact Dr. Xu directly or speak with any of the other faculty at the beginning or end of class.
Oncology 703 – Fall 2009
Class Syllabus
|
Date |
Lecturer |
Title |
|
9/2 |
Bradfield |
Introduction/Env and Cancer |
|
9/4 |
Bradfield |
Liver Cancer |
|
9/9 |
Bradfield |
Chemical Carcinogenesis I |
|
9/11 |
Bradfield |
Chemical Carcinogenesis II |
| 9/14 | Lambert | Introduction to Tumor Virology |
|
9/16 |
Lambert |
Oncogenic Retroviruses |
|
9/18 |
Lambert |
Insertional Mutagenic Retroviruses |
|
9/21 |
Lambert |
Epstein Barr Virus |
|
9/23 |
Lambert |
Kaposi's Sarcoma/Herpes Virus |
|
9/25 |
Lambert |
Adenovirus/SV40 and Tumor Suppressors |
|
9/28 |
Lambert |
Human Papillomaviruses I |
|
9/30 |
McNeel (Lambert) |
Tumor Immunology I |
|
10/2 |
Lambert |
Human Papillomaviruses II |
|
10/5 |
Albertini (Lambert) |
Tumor Immunology II |
|
10/7 |
Tibbetts |
DNA Repair |
|
10/9 |
Tibbetts |
DNA Damage Signaling |
|
10/12 |
Tibbetts |
DNA Damage Checkpoints and Tumor Suppression |
|
10/14 |
Xu |
Cancer Epigenetics I: Introduction & DNA Methylation |
|
10/16 |
Xu |
Cancer Epigenetics II: Histone Modifications I |
|
10/19 |
Xu |
Cancer Epigenetics III: Histone Modifications II |
|
10/21 |
Xu |
Cancer Epigenetics IV: Chromatin Remodeling |
|
10/23 |
Xu |
Cancer Epigenetics V: Non-coding RNA |
|
10/26 |
Zhang |
Leukemia I: Introduction |
|
10/28 |
Zhang |
Leukemia II: Tumor Initiating Cells |
|
10/30 |
Zhang |
Leukemia III: Philadelphia Chromosome |
|
11/2 |
Zhang |
Leukemia IV: Mechanism Based Tumor Therapies |
|
11/4 |
Hoover-Regan |
Childhood Leukemia |
|
11/6 |
Zhang |
Leukemia V: Oncogenesis and the Microenvironment |
|
11/9 |
Xu |
Breast Cancer I: Introduction, Risk Factors |
|
11/11 |
Xu |
Breast Cancer II: Estrogen, SERMS and Aromatase |
|
11/13 |
Xu |
Breast Cancer III: Experimental Models |
|
11/16 |
Xu |
Breast Cancer IV: Genetics |
|
11/18 |
Marker |
Prostate Cancer I |
|
11/20 |
Marker |
Prostate Cancer II |
|
11/23 |
Alexander (Friedl) |
Lecture on Pathology |
|
11/25 |
Alexander |
Cancer: A Genetic Disease? |
| 11/27 | Thanksgiving Recess - No Class | |
|
11/30 |
Alexander |
Mouse Models of Human Tumors: Intro |
|
12/2 |
Alexander |
Mouse Models of Human Tumors: History |
|
12/4 |
Alexander |
Mouse Models of Human Tumors: Future |
|
12/7 |
Alexander |
Colorectal Cancer: Intro |
|
12/9 |
Alexander |
Colorectal Cancer: FAP |
| 12/11 | Alexander | Colorectal Cancer: HNPCC |
|
12/14 |
Alexander (Roopra) |
Metabolism and Cancer: Caloric Restriction |